Cell type gene expression markers


This is a list of gene expression markers are used to define cell types. Green rows indicate canonical markers (classical markers used to define the cell type).

Summary: 8286 associations (178 cell types, 4679 gene symbols, 29 tissues); Last updated: 27/03/2020 10:44:00 CET

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Description: Leydig cells produce testosterone in the presence of luteinizing hormone and are found adjacent to the seminiferous tubules in the testicle.

Gene expression markers for Leydig cells

Vote(s) Species Official gene symbol UI Sensitivity (human) Sensitivity (mouse) Specificity (human) Specificity (mouse) Marker count Cell type Germ layer Organ Aliases Product description Disease Action
2
Mm Hs IGFBP5 0.075 0 0 0.093 0.07 2 Leydig cells Mesoderm Reproductive insulin like growth factor binding protein 5 flag
2
Mm Hs INHBA 0.013 0 0.636 0.008 0.013 3 Leydig cells Mesoderm Reproductive inhibin subunit beta A flag
2
Mm Hs CYP11A1 0.005 1 0.818 0.003 0.005 3 Leydig cells Mesoderm Reproductive P450SCC,CYP11A cytochrome P450 family 11 subfamily A member 1 Yflag
2
Mm Hs DHCR7 0.018 1 0.182 0.016 0.015 2 Leydig cells Mesoderm Reproductive SLOS 7-dehydrocholesterol reductase Yflag
2
Mm Hs IGF2 0.013 0 0 0.046 0.001 8 Leydig cells Mesoderm Reproductive FLJ44734,IGF-II,C11orf43 insulin like growth factor 2 Yflag
1
Mm Hs PRLR 0.013 0 0.727 0.011 0.013 6 Leydig cells Mesoderm Reproductive prolactin receptor Yflag
1
Mm Hs LHCGR 0 1 0.273 0 0 2 Leydig cells Mesoderm Reproductive LHR,LCGR,LGR2,HHG luteinizing hormone/choriogonadotropin receptor Yflag
1
Mm Hs CYP19A1 0 0 0 0.002 0 2 Leydig cells Mesoderm Reproductive ARO,P-450AROM,CPV1,ARO1,CYAR,aromatase,CYP19 cytochrome P450 family 19 subfamily A member 1 Yflag
1
Mm Hs CYP17A1 0.001 1 0.636 0.001 0.001 1 Leydig cells Mesoderm Reproductive P450C17,CPT7,S17AH,CYP17 cytochrome P450 family 17 subfamily A member 1 Yflag
1
Mm Hs LCN2 0.043 0 0.182 0.057 0.042 9 Leydig cells Mesoderm Reproductive NGAL,24p3 lipocalin 2 flag
0
Mm REN1 0 NA NA NA NA 2 Leydig cells Mesoderm Reproductive renin 1 structural flag
0
Mm AKR1CL 0.005 0 1 0 0.005 2 Leydig cells Mesoderm Reproductive aldo-keto reductase family 1, member C-like flag
0
Mm Hs CYP26B1 0.005 0 0.455 0.001 0.005 1 Leydig cells Mesoderm Reproductive P450RAI-2 cytochrome P450 family 26 subfamily B member 1 Yflag
0
Mm Hs ASS1 0.048 0 0.364 0.041 0.048 4 Leydig cells Mesoderm Reproductive CTLN1,ASS argininosuccinate synthase 1 Yflag
0
Mm Hs CFD 0.018 0 0 0.099 0.001 4 Leydig cells Mesoderm Reproductive ADN,DF,PFD complement factor D Yflag
0
Mm Hs DLK1 0.055 0 0.273 0.046 0.058 5 Leydig cells Mesoderm Reproductive FA1,pG2,Pref-1,ZOG,Delta1 delta like non-canonical Notch ligand 1 flag
0
Mm Hs IGFBP3 0.031 0 0 0.059 0.026 4 Leydig cells Mesoderm Reproductive IBP3,BP-53 insulin like growth factor binding protein 3 flag
0
Mm Hs PTGDS 0.054 1 0.182 0.058 0.055 10 Leydig cells Mesoderm Reproductive L-PGDS prostaglandin D2 synthase flag
0
Mm Hs VIT 0.005 0 0 0.001 0 1 Leydig cells Mesoderm Reproductive vitrin flag
0
Mm Hs ALDH1A3 0.008 0 0 0.035 0.003 5 Leydig cells Mesoderm Reproductive RALDH3,ALDH6 aldehyde dehydrogenase 1 family member A3 Yflag
0
Mm Hs NOS1 0.004 0 0 0 0.004 3 Leydig cells Mesoderm Reproductive nNOS nitric oxide synthase 1 flag
0
Mm Hs EDNRA 0.013 0 0.091 0.01 0.015 2 Leydig cells Mesoderm Reproductive ET-A,ETA-R,hET-AR endothelin receptor type A Yflag
0
Mm Hs SMOC2 0.026 1 0 0.017 0 4 Leydig cells Mesoderm Reproductive SMAP2 SPARC related modular calcium binding 2 Yflag
0
Mm Hs ADAM21 0.001 0 0 0.003 0 1 Leydig cells Mesoderm Reproductive ADAM31 ADAM metallopeptidase domain 21 flag
0
Mm Hs ESRRG 0.002 0 0 0.004 0.002 1 Leydig cells Mesoderm Reproductive NR3B3,ERRg,ERR-gamma estrogen related receptor gamma flag
0
Mm Hs GPRC6A 0 0 0 0 0 1 Leydig cells Mesoderm Reproductive bA86F4.3 G protein-coupled receptor class C group 6 member A flag
0
Mm Hs GJA1 0.1 1 0.455 0.063 0.107 4 Leydig cells Mesoderm Reproductive CX43,ODOD,SDTY3,ODDD,GJAL gap junction protein alpha 1 Yflag
0
Mm Hs GAS6 0.1 0 0.727 0.044 0.114 1 Leydig cells Mesoderm Reproductive AXSF,FLJ34709,DKFZp666G247,AXLLG growth arrest specific 6 flag
0
Mm Hs SULT1E1 0.002 0 0 0.006 0 3 Leydig cells Mesoderm Reproductive STE sulfotransferase family 1E member 1 flag
0
Mm Hs PLAUR 0.052 0 0 0.107 0.039 1 Leydig cells Mesoderm Reproductive URKR,UPAR,CD87 plasminogen activator, urokinase receptor flag
0
Mm Hs FABP9 0.008 0 0.091 0 0.01 2 Leydig cells Mesoderm Reproductive PERF,T-FABP,PERF15 fatty acid binding protein 9 flag
0
Mm Hs CALB2 0.03 1 0 0.002 0.037 8 Leydig cells Mesoderm Reproductive CAL2 calbindin 2 flag
0
Mm Hs MAFB 0.053 0 0 0.059 0.053 6 Leydig cells Mesoderm Reproductive KRML MAF bZIP transcription factor B Yflag
0
Mm Hs ALDH1A1 0.039 0 0.909 0.088 0.028 5 Leydig cells Mesoderm Reproductive RALDH1,PUMB1,ALDH1 aldehyde dehydrogenase 1 family member A1 flag
0
Mm Hs SLC9A8 0.001 0 0 0 0 3 Leydig cells Mesoderm Reproductive KIAA0939,NHE8 solute carrier family 9 member A8 flag
0
Mm Hs KISS1 0.001 0 0 0.003 0 1 Leydig cells Mesoderm Reproductive KiSS-1 metastasis suppressor Yflag
0
Mm Hs PDE8A 0.015 0 0.091 0.004 0.018 2 Leydig cells Mesoderm Reproductive HsT19550 phosphodiesterase 8A flag
0
Mm Hs LEP 0 0 0 0 0 3 Leydig cells Mesoderm Reproductive OBS leptin Yflag
0
Mm Hs CXCL10 0.009 0 0 0.01 0.009 3 Leydig cells Mesoderm Reproductive IFI10,IP-10,crg-2,mob-1,C7,gIP-10,INP10,SCYB10 C-X-C motif chemokine ligand 10 flag
0
Mm Hs PTCH1 0.012 0 0.182 0.019 0.011 4 Leydig cells Mesoderm Reproductive BCNS,NBCCS,PTCH patched 1 Yflag
0
Mm Hs GATA4 0.008 0 0.182 0.005 0.008 6 Leydig cells Mesoderm Reproductive GATA binding protein 4 Yflag
0
Mm Hs ACSBG1 0.023 0 0.909 0 0.028 3 Leydig cells Mesoderm Reproductive BGM,FLJ30320,MGC14352,BG1,KIAA0631,hBG1,hsBG acyl-CoA synthetase bubblegum family member 1 flag
0
Mm Hs INHA 0.006 1 0.727 0.013 0.004 3 Leydig cells Mesoderm Reproductive inhibin subunit alpha flag
0
Mm Hs IGF1 0.044 0 0.182 0.003 0.054 4 Leydig cells Mesoderm Reproductive IGF1A,IGFI,IGF-I,IGF insulin like growth factor 1 Yflag
0
Mm Hs INSL3 0.001 1 0.545 0.001 0 1 Leydig cells Mesoderm Reproductive RLF,MGC119818,MGC119819,RLNL insulin like 3 Yflag
0
Mm Hs NR5A2 0.003 0 0 0 0.004 2 Leydig cells Mesoderm Reproductive FTZ-F1beta,hB1F,FTZ-F1,hB1F-2,B1F2,LRH1,FTF nuclear receptor subfamily 5 group A member 2 flag
0
Mm Hs MLANA 0.002 0 0 0 0.002 3 Leydig cells Mesoderm Reproductive melan-A flag
0
Mm Hs RLN1 0 0 0 0 0 1 Leydig cells Mesoderm Reproductive relaxin 1 flag
0
Hs RLN2 0.001 0 0 0.007 0 1 Leydig cells Mesoderm Reproductive RLXH2,bA12D24.1.1,bA12D24.1.2 relaxin 2 flag
0
Mm Hs RLN3 0 0 0 0 0 1 Leydig cells Mesoderm Reproductive ZINS4,RXN3 relaxin 3 flag
0
Mm Hs TAC1 0.01 0 0 0.005 0 6 Leydig cells Mesoderm Reproductive NPK,TAC2,NKNA tachykinin precursor 1 flag
0
Mm Hs STAR 0.001 0.5 0 0 0 3 Leydig cells Mesoderm Reproductive StAR,STARD1 steroidogenic acute regulatory protein Yflag
0
Mm Hs THBS2 0.01 0 0 0.003 0 2 Leydig cells Mesoderm Reproductive TSP2 thrombospondin 2 Yflag
0
Mm Hs HSD11B2 0.004 0 0 0.011 0.003 2 Leydig cells Mesoderm Reproductive SDR9C3 hydroxysteroid 11-beta dehydrogenase 2 Yflag
-1
Mm Hs HSD17B3 0.002 1 0.182 0.002 0.002 2 Leydig cells Mesoderm Reproductive SDR12C2 hydroxysteroid 17-beta dehydrogenase 3 Yflag
-1
Mm Hs HSD3B1 0.001 0 0.818 0.001 0.001 3 Leydig cells Mesoderm Reproductive SDR11E1,HSDB3,HSD3B hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 flag

Datasets with computationally identified Leydig cells

SRA SRS tissue cluster cell type p-value FDR View
SRA742982 SRS3565399 Testis 10 Leydig cells 2.80E-5 5.19E-3 view data
SRA638923 SRS2797101 Ovary 2 Leydig cells 6.27E-7 2.96E-4 view data
SRA742982 SRS3565401 Testis 9 Leydig cells 2.50E-6 8.08E-4 view data
SRA742982 SRS3565397 Testis 9 Leydig cells 6.73E-7 2.80E-4 view data
SRA742982 SRS3565397 Testis 19 Leydig cells 3.88E-5 8.05E-3 view data
SRA638923 SRS2797100 Ovary 3 Leydig cells 1.01E-6 4.41E-4 view data
SRA826293 SRS4181130 Testis 17 Leydig cells 1.26E-8 4.86E-6 view data
SRA826293 SRS4181129 Testis 15 Leydig cells 5.64E-7 1.26E-4 view data
SRA742982 SRS3565409 Testis 10 Leydig cells 1.95E-7 6.93E-5 view data
SRA645836 SRS2823483 Testis 6 Leydig cells 2.80E-5 3.40E-3 view data
SRA645836 SRS2823483 Testis 12 Leydig cells 6.97E-11 2.48E-8 view data
SRA638923 SRS2797118 Testis 10 Leydig cells 2.60E-13 5.04E-11 view data
SRA645779 SRS2823375 Testis 17 Leydig cells 1.27E-13 2.38E-11 view data