Cell type gene expression markers


This is a list of gene expression markers are used to define cell types. Green rows indicate canonical markers (classical markers used to define the cell type).

Summary: 8286 associations (178 cell types, 4679 gene symbols, 29 tissues); Last updated: 27/03/2020 10:44:00 CET

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Description: In the small intestine, Paneth cells residing at the bottom of the intestinal crypts are the key effectors of innate mucosal defense. Paneth cells produce large amounts of α-defensins and other antimicrobial peptides, such as lysozymes and secretory phospholipase A2 (sPLA2).

Gene expression markers for Paneth cells

Vote(s) Species Official gene symbol UI Sensitivity (human) Sensitivity (mouse) Specificity (human) Specificity (mouse) Marker count Cell type Germ layer Organ Aliases Product description Disease Action
5
Mm Hs MMP7 0.007 0 0.425 0.025 0.001 4 Paneth cells Endoderm GI tract PUMP-1,MPSL1 matrix metallopeptidase 7 flag
5
Mm Hs DEFA5 0.003 0 0.45 0.001 0.001 1 Paneth cells Endoderm GI tract HD-5,DEF5 defensin alpha 5 flag
5
Mm LYZ1 0.031 0 0.938 0 0.033 4 Paneth cells Endoderm GI tract lysozyme 1 flag
2
Mm MPTX2 0.003 0 0.513 0 0.001 1 Paneth cells Endoderm GI tract mucosal pentraxin 2 flag
1
Mm Hs ADIPOQ 0.004 0 0 0 0.005 3 Paneth cells Endoderm GI tract ACRP30,AdipoQ,apM1,GBP28,adiponectin,ACDC adiponectin, C1Q and collagen domain containing Yflag
1
Hs LYZ 0.008 0 0 0.041 0 6 Paneth cells Endoderm GI tract lysozyme Yflag
1
Hs DEFA6 0 0 0 0 0 1 Paneth cells Endoderm GI tract HD-6,DEF6 defensin alpha 6 flag
0
Mm Hs WNT3 0.003 0 0 0.001 0 2 Paneth cells Endoderm GI tract MGC131950,MGC138321,MGC138323 Wnt family member 3 Yflag
0
Mm Hs KCNN4 0.027 0 0.125 0.01 0.029 3 Paneth cells Endoderm GI tract KCa3.1,hSK4,hKCa4,hIKCa1,IK potassium calcium-activated channel subfamily N member 4 Yflag
0
Mm Hs RAP1A 0.314 0 0 0.17 0 1 Paneth cells Endoderm GI tract KREV-1,SMGP21 RAP1A, member of RAS oncogene family flag
0
Mm Hs TLR5 0 0 0 0 0 2 Paneth cells Endoderm GI tract TIL3,MGC126430,MGC126431,SLEB1 toll like receptor 5 Yflag
0
Mm DEFA20 0 0 0.1 0 0 1 Paneth cells Endoderm GI tract defensin, alpha, 20 flag
0
Mm Hs ATG16L1 0.003 0 0 0.001 0.003 1 Paneth cells Endoderm GI tract WDR30,FLJ10035,ATG16A,APG16L,ATG16L autophagy related 16 like 1 Yflag
0
Mm Hs WNT9B 0 0 0 0 0 1 Paneth cells Endoderm GI tract WNT14B,WNT15 Wnt family member 9B flag
0
Mm Hs DLL4 0.007 0 0 0.003 0.008 2 Paneth cells Endoderm GI tract delta like canonical Notch ligand 4 Yflag
0
Hs IL4R 0.002 0 0 0.01 0 4 Paneth cells Endoderm GI tract CD124 interleukin 4 receptor Yflag
0
Mm IL4RA 0.013 0 0.025 0 0.017 5 Paneth cells Endoderm GI tract interleukin 4 receptor, alpha flag
0
Mm Hs TLR9 0 0 0 0 0 7 Paneth cells Endoderm GI tract CD289 toll like receptor 9 flag
0
Mm Hs CTNNB1 0.052 0 0 0.212 0.011 8 Paneth cells Endoderm GI tract beta-catenin,armadillo,CTNNB catenin beta 1 Yflag
0
Mm Hs TM4SF20 0.019 0 0 0.003 0 2 Paneth cells Endoderm GI tract FLJ22800,TCCE518 transmembrane 4 L six family member 20 Yflag
0
Mm DEFA23 0.003 0 0.575 0 0.001 1 Paneth cells Endoderm GI tract defensin, alpha, 23 flag
0
Mm Hs DEFA3 0.002 0 0.4 0 0.001 2 Paneth cells Endoderm GI tract HNP-3 defensin alpha 3 flag
0
Mm DEFA26 0.003 0 0.55 0 0.001 1 Paneth cells Endoderm GI tract defensin, alpha, 26 flag
0
Mm DEFA17 0.007 0 0.9 0 0.004 1 Paneth cells Endoderm GI tract defensin, alpha, 17 flag
0
Mm DEFA21 0.007 0 0.713 0 0.006 1 Paneth cells Endoderm GI tract defensin, alpha, 21 flag
0
Mm DEFA22 0.007 0 0.675 0 0.005 1 Paneth cells Endoderm GI tract defensin, alpha, 22 flag
0
Mm DEFA24 0.017 0 1 0 0.017 2 Paneth cells Endoderm GI tract defensin, alpha, 24 flag
0
Mm Hs MPTX1 0.001 0 0.025 0 0.001 1 Paneth cells Endoderm GI tract mucosal pentraxin 1 (pseudogene) flag
0
Mm Hs KLF15 0.001 0 0 0 0.002 1 Paneth cells Endoderm GI tract KKLF Kruppel like factor 15 flag
0
Mm Hs RETNLB 0.003 0 0 0.002 0 1 Paneth cells Endoderm GI tract HXCP2,FIZZ2,RELMb resistin like beta flag
0
Mm Hs CSF2 0.002 0 0 0.009 0.001 4 Paneth cells Endoderm GI tract GM-CSF,GMCSF colony stimulating factor 2 flag
0
Mm Hs PLA2G2A 0.009 0 0.675 0.025 0.002 1 Paneth cells Endoderm GI tract PLA2B phospholipase A2 group IIA Yflag
0
Mm Hs PRSS1 0.002 0 0 0.01 0 2 Paneth cells Endoderm GI tract TRY1 serine protease 1 Yflag
0
Mm Hs GUCA2B 0.019 0 0.863 0.008 0.018 1 Paneth cells Endoderm GI tract guanylate cyclase activator 2B flag
0
Mm REG3B 0.013 NA NA NA NA 1 Paneth cells Endoderm GI tract regenerating islet-derived 3 beta flag
0
Mm Hs MUC2 0.007 0 0.638 0.006 0.004 2 Paneth cells Endoderm GI tract mucin 2, oligomeric mucus/gel-forming flag
0
Mm Hs CLCA1 0.003 0 0.138 0.002 0.003 2 Paneth cells Endoderm GI tract CaCC,CLCRG1 chloride channel accessory 1 flag
0
Mm Hs GUCA2A 0.015 0 0.725 0.016 0.012 3 Paneth cells Endoderm GI tract STARA,GUCA2 guanylate cyclase activator 2A flag
0
Hs DEFA1 0 0 0 0 0 2 Paneth cells Endoderm GI tract HNP-1,DEF1,DEFA2 defensin alpha 1 flag
0
Mm Hs ITLN1 0.009 0 0.875 0.006 0.006 2 Paneth cells Endoderm GI tract ITLN,FLJ20022,LFR,HL-1,hIntL intelectin 1 flag
0
Mm Hs RIPK2 0.004 0 0 0.014 0 1 Paneth cells Endoderm GI tract RICK,CARDIAK,CARD3 receptor interacting serine/threonine kinase 2 flag
0
Mm ANG4 0.005 0 0.713 0 0.002 1 Paneth cells Endoderm GI tract angiogenin, ribonuclease A family, member 4 flag
0
Mm Hs GPX2 0.04 0 0.738 0.048 0.034 1 Paneth cells Endoderm GI tract GSHPX-GI glutathione peroxidase 2 flag
0
Mm Hs LGALS2 0.032 0 0.863 0.038 0.027 5 Paneth cells Endoderm GI tract HL14 galectin 2 Yflag
0
Mm Hs SPINK4 0.014 0 0 0.006 0 2 Paneth cells Endoderm GI tract PEC-60,MGC133107 serine peptidase inhibitor, Kazal type 4 flag
0
Mm Hs FABP4 0.028 0 0 0.01 0.033 10 Paneth cells Endoderm GI tract A-FABP,aP2 fatty acid binding protein 4 flag
0
Mm Hs CFD 0.018 0 0 0.099 0.001 4 Paneth cells Endoderm GI tract ADN,DF,PFD complement factor D Yflag
0
Mm Hs PNLIPRP2 0.003 0 0.313 0.002 0.002 1 Paneth cells Endoderm GI tract PLRP2 pancreatic lipase related protein 2 (gene/pseudogene) flag
0
Mm Hs DMBT1 0.01 0 0.238 0.003 0.01 3 Paneth cells Endoderm GI tract GP340,muclin,SALSA,Gp-340,hensin,vomeroglandin deleted in malignant brain tumors 1 flag
0
Mm Hs NOD2 0 0 0 0 0 3 Paneth cells Endoderm GI tract BLAU,PSORAS1,CLR16.3,NLRC2,IBD1,CARD15 nucleotide binding oligomerization domain containing 2 Yflag
0
Mm Hs AGR2 0.024 0 0.788 0.073 0.009 7 Paneth cells Endoderm GI tract XAG-2,HAG-2,PDIA17 anterior gradient 2, protein disulphide isomerase family member flag
-1
Mm Hs DLL1 0.003 0 0 0.005 0.003 2 Paneth cells Endoderm GI tract delta like canonical Notch ligand 1 flag
-1
Mm Hs REG3G 0.017 0 0 0.002 0 1 Paneth cells Endoderm GI tract UNQ429,LPPM429,PAP1B regenerating family member 3 gamma flag
-1
Mm Hs LGR4 0.017 0 0.038 0.013 0.017 1 Paneth cells Endoderm GI tract GPR48 leucine rich repeat containing G protein-coupled receptor 4 Yflag

Datasets with computationally identified Paneth cells

SRA SRS tissue cluster cell type p-value FDR View
SRA628138 SRS2659226 Intestinal organoid epithelial cells 11 Paneth cells 7.48E-7 9.71E-5 view data
SRA628138 SRS2659229 Intestinal organoid epithelial cells 8 Paneth cells 1.00E-11 1.97E-9 view data
SRA638923 SRS2797112 Small intestine 1 Paneth cells 2.79E-8 3.20E-6 view data
SRA638923 SRS2797112 Small intestine 5 Paneth cells 2.70E-7 2.50E-5 view data
SRA638923 SRS2797112 Small intestine 9 Paneth cells 4.93E-35 1.19E-31 view data
SRA638923 SRS2797112 Small intestine 10 Paneth cells 9.89E-9 1.49E-6 view data
SRA638923 SRS2797112 Small intestine 11 Paneth cells 1.37E-6 1.14E-4 view data
SRA638923 SRS2797112 Small intestine 13 Paneth cells 8.82E-9 1.42E-6 view data
SRA508949 SRS1876796 Small intestine 6 Paneth cells 1.14E-16 2.22E-14 view data
SRA508949 SRS1876784 Small intestine 7 Paneth cells 8.51E-16 2.30E-13 view data
SRA508949 SRS1876791 Small intestine 4 Paneth cells 2.23E-6 2.80E-4 view data
SRA508949 SRS1876791 Small intestine 5 Paneth cells 2.50E-16 8.64E-14 view data
SRA877776 SRS4655564 Distal small intestine 8 Paneth cells 1.29E-38 4.28E-36 view data
SRA628138 SRS2659223 Intestinal organoid epithelial cells 5 Paneth cells 1.47E-4 1.68E-2 view data
SRA745734 SRS3600976 Intestinal epithelium 6 Paneth cells 2.76E-12 2.51E-10 view data
SRA639854 SRS2766803 Intestinal crypt epithelium 5 Paneth cells 3.00E-11 1.58E-8 view data
SRA628138 SRS2659233 Intestinal organoid epithelial cells 4 Paneth cells 8.55E-13 3.35E-10 view data
SRA508949 SRS1876787 Small intestine 4 Paneth cells 1.39E-16 3.85E-14 view data
SRA638923 SRS2797114 Small intestine 4 Paneth cells 1.27E-38 1.28E-35 view data
SRA638923 SRS2797111 Small intestine 1 Paneth cells 1.00E-4 9.92E-3 view data
SRA638923 SRS2797111 Small intestine 2 Paneth cells 1.24E-38 5.79E-36 view data
SRA745734 SRS3600974 Intestinal epithelium 0 Paneth cells 9.40E-23 2.34E-20 view data
SRA745734 SRS3600974 Intestinal epithelium 3 Paneth cells 3.10E-25 9.27E-23 view data
SRA745734 SRS3600974 Intestinal epithelium 7 Paneth cells 7.50E-27 2.81E-24 view data
SRA745734 SRS3600974 Intestinal epithelium 8 Paneth cells 1.16E-37 8.65E-35 view data
SRA745734 SRS3600974 Intestinal epithelium 11 Paneth cells 5.21E-26 1.73E-23 view data
SRA745734 SRS3600974 Intestinal epithelium 13 Paneth cells 1.38E-20 2.95E-18 view data
SRA745734 SRS3600974 Intestinal epithelium 14 Paneth cells 4.78E-17 6.21E-15 view data
SRA745734 SRS3600974 Intestinal epithelium 15 Paneth cells 5.55E-17 6.92E-15 view data
SRA745734 SRS3600974 Intestinal epithelium 16 Paneth cells 4.26E-19 7.49E-17 view data
SRA628138 SRS2659231 Intestinal organoid epithelial cells 4 Paneth cells 4.02E-10 9.74E-8 view data
SRA508949 SRS1876792 Small intestine 4 Paneth cells 1.65E-7 2.28E-5 view data
SRA508949 SRS1876792 Small intestine 6 Paneth cells 4.22E-16 1.46E-13 view data
SRA628138 SRS2659230 Intestinal organoid epithelial cells 7 Paneth cells 1.62E-15 6.80E-13 view data
SRA508949 SRS1876793 Small intestine 3 Paneth cells 1.05E-5 1.16E-3 view data
SRA508949 SRS1876793 Small intestine 5 Paneth cells 6.56E-12 1.13E-9 view data
SRA745734 SRS3600975 Intestinal epithelium 0 Paneth cells 1.75E-19 2.96E-17 view data
SRA745734 SRS3600975 Intestinal epithelium 2 Paneth cells 1.26E-25 7.47E-23 view data
SRA745734 SRS3600975 Intestinal epithelium 5 Paneth cells 2.55E-14 2.53E-12 view data
SRA745734 SRS3600975 Intestinal epithelium 6 Paneth cells 7.52E-13 7.04E-11 view data
SRA745734 SRS3600975 Intestinal epithelium 7 Paneth cells 3.66E-23 1.19E-20 view data
SRA745734 SRS3600975 Intestinal epithelium 10 Paneth cells 3.31E-19 5.35E-17 view data
SRA745734 SRS3600975 Intestinal epithelium 14 Paneth cells 1.72E-11 1.36E-9 view data
SRA745734 SRS3600975 Intestinal epithelium 15 Paneth cells 2.06E-12 1.74E-10 view data
SRA745734 SRS3600975 Intestinal epithelium 16 Paneth cells 3.53E-18 5.02E-16 view data
SRA745734 SRS3600975 Intestinal epithelium 17 Paneth cells 3.41E-16 3.79E-14 view data
SRA745734 SRS3600975 Intestinal epithelium 18 Paneth cells 1.52E-18 2.25E-16 view data
SRA745734 SRS3600975 Intestinal epithelium 19 Paneth cells 6.71E-16 7.24E-14 view data
SRA508949 SRS1876788 Small intestine 5 Paneth cells 8.72E-21 5.19E-18 view data
SRA639854 SRS2766801 Intestinal crypt epithelium 0 Paneth cells 1.30E-5 2.43E-3 view data
SRA639854 SRS2766801 Intestinal crypt epithelium 4 Paneth cells 1.38E-9 8.80E-7 view data
SRA639854 SRS2766801 Intestinal crypt epithelium 8 Paneth cells 5.12E-5 6.52E-3 view data
SRA639854 SRS2766801 Intestinal crypt epithelium 9 Paneth cells 9.85E-8 3.14E-5 view data
SRA639854 SRS2766801 Intestinal crypt epithelium 11 Paneth cells 6.74E-5 7.95E-3 view data
SRA639854 SRS2766801 Intestinal crypt epithelium 15 Paneth cells 4.46E-6 9.46E-4 view data
SRA639854 SRS2766801 Intestinal crypt epithelium 16 Paneth cells 1.04E-4 1.03E-2 view data
SRA508949 SRS1876783 Small intestine 6 Paneth cells 5.00E-15 9.66E-13 view data
SRA877776 SRS4655561 Distal small intestine 8 Paneth cells 3.79E-15 6.52E-13 view data
SRA877776 SRS4655561 Distal small intestine 9 Paneth cells 3.56E-10 3.18E-8 view data
SRA877776 SRS4655561 Distal small intestine 10 Paneth cells 3.69E-36 2.22E-33 view data
SRA877776 SRS4655561 Distal small intestine 11 Paneth cells 1.50E-11 1.71E-9 view data
SRA628138 SRS2659249 Intestinal organoid epithelial cells 9 Paneth cells 5.07E-11 1.20E-8 view data
SRA745734 SRS3600977 Intestinal epithelium 0 Paneth cells 2.38E-27 6.86E-25 view data
SRA745734 SRS3600977 Intestinal epithelium 1 Paneth cells 6.53E-24 1.48E-21 view data
SRA745734 SRS3600977 Intestinal epithelium 2 Paneth cells 1.07E-14 1.22E-12 view data
SRA745734 SRS3600977 Intestinal epithelium 3 Paneth cells 5.96E-40 3.15E-37 view data
SRA745734 SRS3600977 Intestinal epithelium 9 Paneth cells 2.65E-28 8.40E-26 view data
SRA745734 SRS3600977 Intestinal epithelium 10 Paneth cells 5.02E-19 7.95E-17 view data
SRA745734 SRS3600977 Intestinal epithelium 12 Paneth cells 2.31E-34 1.05E-31 view data
SRA745734 SRS3600977 Intestinal epithelium 13 Paneth cells 3.73E-33 1.48E-30 view data
SRA745734 SRS3600977 Intestinal epithelium 14 Paneth cells 3.25E-19 5.41E-17 view data
SRA745734 SRS3600977 Intestinal epithelium 15 Paneth cells 2.66E-27 7.02E-25 view data
SRA745734 SRS3600977 Intestinal epithelium 16 Paneth cells 2.55E-19 4.48E-17 view data
SRA745734 SRS3600977 Intestinal epithelium 17 Paneth cells 9.45E-22 2.00E-19 view data
SRA628138 SRS2659221 Intestinal organoid epithelial cells 3 Paneth cells 2.58E-12 1.29E-9 view data
SRA628138 SRS2659220 Intestinal organoid epithelial cells 8 Paneth cells 4.87E-12 1.11E-9 view data
SRA877776 SRS4655562 Distal small intestine 9 Paneth cells 6.82E-42 5.54E-39 view data
SRA877776 SRS4655562 Distal small intestine 10 Paneth cells 1.49E-10 1.91E-8 view data
SRA877776 SRS4655562 Distal small intestine 11 Paneth cells 1.71E-8 1.73E-6 view data
SRA508949 SRS1876794 Small intestine 7 Paneth cells 1.52E-15 4.22E-13 view data
SRA508949 SRS1876795 Small intestine 7 Paneth cells 1.66E-16 3.57E-14 view data
SRA877776 SRS4655563 Distal small intestine 5 Paneth cells 6.80E-10 6.94E-8 view data
SRA877776 SRS4655563 Distal small intestine 7 Paneth cells 9.85E-35 3.45E-32 view data
SRA638923 SRS2797113 Small intestine 4 Paneth cells 8.70E-37 8.77E-34 view data
SRA877776 SRS4655560 Distal small intestine 6 Paneth cells 1.16E-8 7.63E-7 view data
SRA877776 SRS4655560 Distal small intestine 7 Paneth cells 1.22E-35 1.07E-32 view data
SRA877776 SRS4655560 Distal small intestine 8 Paneth cells 1.99E-20 4.97E-18 view data