Cell type gene expression markers


This is a list of gene expression markers are used to define cell types. Green rows indicate canonical markers (classical markers used to define the cell type).

Summary: 8286 associations (178 cell types, 4679 gene symbols, 29 tissues); Last updated: 27/03/2020 10:44:00 CET

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Description: Type I alveolar cells are squamous (giving more surface area to each cell) and cover approximately 90–95% of the alveolar surface. Type I cells are involved in the process of gas exchange between the alveoli and blood. These cells are extremely thin (sometimes only 25 nm) – the electron microscope was needed to prove that all alveoli are covered with an epithelial lining. These cells need to be so thin to be readily permeable for enabling an easy gas exchange between the alveoli and the blood.

Gene expression markers for Pulmonary alveolar type I cells

Vote(s) Species Official gene symbol UI Sensitivity (human) Sensitivity (mouse) Specificity (human) Specificity (mouse) Marker count Cell type Germ layer Organ Aliases Product description Disease Action
5
Mm Hs CLDN18 0.01 0 1 0.004 0.01 3 Pulmonary alveolar type I cells Endoderm Lungs SFTPJ claudin 18 flag
2
Mm Hs RTKN2 0.007 0 0 0.028 0 1 Pulmonary alveolar type I cells Endoderm Lungs Em:AC024597.2,bA531F24.1,FLJ39352,PLEKHK1 rhotekin 2 flag
2
Mm Hs COL4A3 0.006 0 0.971 0.001 0.005 4 Pulmonary alveolar type I cells Endoderm Lungs collagen type IV alpha 3 chain Yflag
1
Mm Hs FSTL3 0.004 0 0 0.015 0 1 Pulmonary alveolar type I cells Endoderm Lungs FLRG,FSRP follistatin like 3 flag
1
Mm Hs SEMA3B 0.009 0 0 0.018 0 3 Pulmonary alveolar type I cells Endoderm Lungs SemA,semaV,LUCA-1,sema5,SEMAA semaphorin 3B flag
1
Mm Hs VEGFA 0.021 0 0 0.025 0 10 Pulmonary alveolar type I cells Endoderm Lungs VEGF-A,VPF,VEGF vascular endothelial growth factor A Yflag
1
Mm Hs AGER 0.011 0 1 0.001 0.011 6 Pulmonary alveolar type I cells Endoderm Lungs SCARJ1 advanced glycosylation end-product specific receptor flag
1
Mm Hs COL4A4 0.007 0 0.882 0.003 0.006 4 Pulmonary alveolar type I cells Endoderm Lungs CA44 collagen type IV alpha 4 chain Yflag
1
Mm Hs CYP4B1 0.018 0 0.588 0.013 0.018 3 Pulmonary alveolar type I cells Endoderm Lungs cytochrome P450 family 4 subfamily B member 1 flag
1
Mm Hs CLIC5 0.016 0 0.971 0.013 0.015 2 Pulmonary alveolar type I cells Endoderm Lungs DFNB102 chloride intracellular channel 5 Yflag
0
Mm Hs PDPN 0.062 0 0.971 0.023 0.07 4 Pulmonary alveolar type I cells Endoderm Lungs T1A-2,Gp38,aggrus,PA2.26 podoplanin flag
0
Mm Hs KRT7 0.056 0 1 0.101 0.045 9 Pulmonary alveolar type I cells Endoderm Lungs CK7,K2C7 keratin 7 flag
0
Mm Hs EMP2 0.065 0 1 0.09 0.055 1 Pulmonary alveolar type I cells Endoderm Lungs XMP epithelial membrane protein 2 Yflag
0
Mm Hs AQP5 0.018 0 1 0.042 0.012 4 Pulmonary alveolar type I cells Endoderm Lungs aquaporin 5 Yflag
0
Mm Hs HOPX 0.033 0 1 0.092 0.02 10 Pulmonary alveolar type I cells Endoderm Lungs LAGY,OB1,NECC1,SMAP31 HOP homeobox flag
0
Mm Hs SEC14L3 0.006 0 0 0 0 3 Pulmonary alveolar type I cells Endoderm Lungs TAP2 SEC14 like lipid binding 3 flag
0
Mm CYP2B10 0.004 0 0.618 0 0.003 2 Pulmonary alveolar type I cells Endoderm Lungs cytochrome P450, family 2, subfamily b, polypeptide 10 flag
0
Mm Hs SCNN1A 0.008 0 0 0.011 0 4 Pulmonary alveolar type I cells Endoderm Lungs ENaCalpha,SCNN1 sodium channel epithelial 1 alpha subunit Yflag
-1
Mm Hs PXDC1 0.028 0 0.824 0.002 0.033 2 Pulmonary alveolar type I cells Endoderm Lungs C6orf145 PX domain containing 1 flag
-1
Mm Hs MMP11 0.01 0 0.324 0.004 0.008 2 Pulmonary alveolar type I cells Endoderm Lungs STMY3 matrix metallopeptidase 11 flag
-1
Mm Hs P2RX7 0.004 0 0 0.009 0.003 8 Pulmonary alveolar type I cells Endoderm Lungs P2X7,MGC20089 purinergic receptor P2X 7 flag
-1
Mm Hs SMARCA1 0.015 0 0 0.041 0 3 Pulmonary alveolar type I cells Endoderm Lungs NURF140,SWI,hSNF2L,SNF2L1,SNF2L SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 flag
-1
Mm Hs RADIL 0 0 0 0 0 1 Pulmonary alveolar type I cells Endoderm Lungs FLJ10324,KIAA1849,RASIP2 Rap associating with DIL domain flag
-1
Mm Hs MEX3B 0.004 0 0 0.011 0.003 1 Pulmonary alveolar type I cells Endoderm Lungs DKFZp434J0617,RNF195,RKHD3 mex-3 RNA binding family member B flag
-1
Mm Hs ICAM1 0.009 0 0.294 0.006 0.009 8 Pulmonary alveolar type I cells Endoderm Lungs CD54 intercellular adhesion molecule 1 Yflag
-1
Mm Hs EGFL6 0.01 0 0 0.008 0.011 3 Pulmonary alveolar type I cells Endoderm Lungs MAEG EGF like domain multiple 6 flag
-1
Mm Hs CRLF1 0.015 0 0.618 0.005 0.016 2 Pulmonary alveolar type I cells Endoderm Lungs CLF-1,CISS,CISS1 cytokine receptor like factor 1 Yflag
-1
Mm Hs AQP3 0.025 0 0 0.071 0.016 8 Pulmonary alveolar type I cells Endoderm Lungs GIL aquaporin 3 (Gill blood group) Yflag
-1
Mm Hs GPRC5A 0.024 0 0.971 0.083 0.008 2 Pulmonary alveolar type I cells Endoderm Lungs RAIG1,PEIG-1,RAI3 G protein-coupled receptor class C group 5 member A flag
-1
Mm Hs IGFBP6 0.039 0 0.676 0.084 0.028 3 Pulmonary alveolar type I cells Endoderm Lungs insulin like growth factor binding protein 6 flag
-1
Mm Hs CTGF 0.028 0 0.618 0.1 0.011 11 Pulmonary alveolar type I cells Endoderm Lungs IGFBP8,CCN2 connective tissue growth factor flag
-1
Mm GRAMD2 0.002 0 0.676 0 0.001 2 Pulmonary alveolar type I cells Endoderm Lungs GRAM domain containing 2 flag
-1
Mm Hs SCNN1B 0.003 0 0 0.003 0 3 Pulmonary alveolar type I cells Endoderm Lungs ENaCbeta sodium channel epithelial 1 beta subunit Yflag
-1
Mm Hs SEMA3E 0.005 0 0 0 0 4 Pulmonary alveolar type I cells Endoderm Lungs M-SemaK,KIAA0331,coll-5,SEMAH semaphorin 3E Yflag
-1
Mm Hs AKAP5 0.006 0 0.971 0 0.006 1 Pulmonary alveolar type I cells Endoderm Lungs AKAP75,AKAP79 A-kinase anchoring protein 5 flag
-2
Mm Hs SCNN1G 0.002 0 0 0 0 3 Pulmonary alveolar type I cells Endoderm Lungs ENaCgamma,SCNEG sodium channel epithelial 1 gamma subunit Yflag

Datasets with computationally identified Pulmonary alveolar type I cells

SRA SRS tissue cluster cell type p-value FDR View
SRA638923 SRS2797073 Lung 9 Pulmonary alveolar type I cells 7.04E-17 4.09E-14 view data
SRA807566 SRS4031560 Lung 5 Pulmonary alveolar type I cells 1.31E-15 1.73E-12 view data
SRA862468 SRS4512241 Lung 14 Pulmonary alveolar type I cells 7.60E-16 3.44E-13 view data
SRA862468 SRS4512237 Lung 17 Pulmonary alveolar type I cells 2.23E-18 1.47E-15 view data
SRA631205 SRS2690038 Pulmonary alveolar type i cells 0 Pulmonary alveolar type I cells 4.78E-23 1.67E-20 view data
SRA631205 SRS2690038 Pulmonary alveolar type i cells 1 Pulmonary alveolar type I cells 5.67E-29 4.97E-26 view data
SRA631205 SRS2690038 Pulmonary alveolar type i cells 2 Pulmonary alveolar type I cells 1.40E-30 2.46E-27 view data
SRA631205 SRS2690038 Pulmonary alveolar type i cells 3 Pulmonary alveolar type I cells 9.78E-23 2.85E-20 view data
SRA631205 SRS2690038 Pulmonary alveolar type i cells 4 Pulmonary alveolar type I cells 4.30E-19 9.40E-17 view data
SRA631205 SRS2690038 Pulmonary alveolar type i cells 5 Pulmonary alveolar type I cells 9.23E-29 5.38E-26 view data
SRA631205 SRS2690038 Pulmonary alveolar type i cells 7 Pulmonary alveolar type I cells 3.22E-24 1.41E-21 view data
SRA631205 SRS2690038 Pulmonary alveolar type i cells 8 Pulmonary alveolar type I cells 2.48E-10 4.33E-8 view data
SRA631205 SRS2690037 Pulmonary alveolar type i cells 0 Pulmonary alveolar type I cells 3.00E-25 2.64E-22 view data
SRA631205 SRS2690037 Pulmonary alveolar type i cells 1 Pulmonary alveolar type I cells 6.71E-29 1.77E-25 view data
SRA631205 SRS2690037 Pulmonary alveolar type i cells 2 Pulmonary alveolar type I cells 1.24E-23 6.56E-21 view data
SRA631205 SRS2690037 Pulmonary alveolar type i cells 3 Pulmonary alveolar type I cells 1.69E-25 2.23E-22 view data
SRA631205 SRS2690037 Pulmonary alveolar type i cells 4 Pulmonary alveolar type I cells 1.68E-23 7.38E-21 view data
SRA631205 SRS2690037 Pulmonary alveolar type i cells 5 Pulmonary alveolar type I cells 4.27E-23 1.61E-20 view data
SRA631205 SRS2690037 Pulmonary alveolar type i cells 6 Pulmonary alveolar type I cells 9.92E-21 2.91E-18 view data
SRA631205 SRS2690037 Pulmonary alveolar type i cells 7 Pulmonary alveolar type I cells 1.51E-21 4.99E-19 view data
SRA862468 SRS4512238 Lung 20 Pulmonary alveolar type I cells 4.79E-21 3.90E-18 view data
SRA862468 SRS4512243 Lung 13 Pulmonary alveolar type I cells 4.38E-17 1.55E-14 view data
SRA807566 SRS4031561 Lung 4 Pulmonary alveolar type I cells 6.93E-24 1.06E-20 view data
SRA837885 SRS4281821 Lung 4 Pulmonary alveolar type I cells 3.46E-17 1.01E-14 view data
SRA631205 SRS2690036 Pulmonary alveolar type i cells 0 Pulmonary alveolar type I cells 5.67E-19 2.16E-16 view data
SRA631205 SRS2690036 Pulmonary alveolar type i cells 1 Pulmonary alveolar type I cells 2.71E-22 2.45E-19 view data
SRA631205 SRS2690036 Pulmonary alveolar type i cells 2 Pulmonary alveolar type I cells 7.55E-20 3.36E-17 view data
SRA631205 SRS2690036 Pulmonary alveolar type i cells 3 Pulmonary alveolar type I cells 2.76E-22 2.45E-19 view data
SRA631205 SRS2690036 Pulmonary alveolar type i cells 4 Pulmonary alveolar type I cells 6.15E-20 3.28E-17 view data
SRA631205 SRS2690036 Pulmonary alveolar type i cells 6 Pulmonary alveolar type I cells 1.56E-14 3.46E-12 view data
SRA631205 SRS2690036 Pulmonary alveolar type i cells 10 Pulmonary alveolar type I cells 3.44E-11 7.08E-9 view data
SRA631205 SRS2690036 Pulmonary alveolar type i cells 11 Pulmonary alveolar type I cells 2.61E-18 8.70E-16 view data
SRA631205 SRS2690036 Pulmonary alveolar type i cells 13 Pulmonary alveolar type I cells 6.85E-17 2.03E-14 view data
SRA837885 SRS4281819 Lung 6 Pulmonary alveolar type I cells 3.79E-21 4.56E-18 view data